Most common salicylate that we use in our daily routine is Aspirin. It is used to manage fever, headache, hangover, all other kinds of pain etc. Its overdose can be accidental or deliberate leading to salicylate poisoning.

1. Mechanism:

Direct effect of salicylate over respiratory center leads to development of respiratory alkalosis while direct effect of salicylic acid in plasma causes metabolic acidosis, which is further potentiated by the development of acute renal failure shortly afterwards.